Article Navigation
- < Previous
- Next >
Journal Article
Get access
, C. Goebel The Procter & Gamble Company, Central Product Safety, Darmstadt, Germany and Cincinnati, OH, U.S.A. Search for other works by this author on: Oxford Academic P.‐J. Coenraads Department of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands Search for other works by this author on: Oxford Academic H. Rothe The Procter & Gamble Company, Central Product Safety, Darmstadt, Germany and Cincinnati, OH, U.S.A. Search for other works by this author on: Oxford Academic G. Kunze The Procter & Gamble Company, Central Product Safety, Darmstadt, Germany and Cincinnati, OH, U.S.A. Search for other works by this author on: Oxford Academic M. Kock The Procter & Gamble Company, Central Product Safety, Darmstadt, Germany and Cincinnati, OH, U.S.A. Search for other works by this author on: Oxford Academic H. Schlatter The Procter & Gamble Company, Central Product Safety, Darmstadt, Germany and Cincinnati, OH, U.S.A. Search for other works by this author on: Oxford Academic G.F. Gerberick The Procter & Gamble Company, Central Product Safety, Darmstadt, Germany and Cincinnati, OH, U.S.A. Search for other works by this author on: Oxford Academic B. Blömeke Department of Environmental Toxicology, Trier University, Am Wissenschaftspark 25–27, 54296 Trier, Germany Correspondence: Brunhilde Blömeke. E‐mail: bloemeke@uni‐trier.de Search for other works by this author on: Oxford Academic
British Journal of Dermatology, Volume 163, Issue 6, 1 December 2010, Pages 1205–1211, https://doi.org/10.1111/j.1365-2133.2010.10009.x
Published:
01 December 2010
- Views
- Article contents
- Figures & tables
- Video
- Audio
- Supplementary Data
-
Cite
Cite
C. Goebel, P.‐J. Coenraads, H. Rothe, G. Kunze, M. Kock, H. Schlatter, G.F. Gerberick, B. Blömeke, Elicitation of the immune response to p‐phenylenediamine in allergic patients: the role of dose and exposure time, British Journal of Dermatology, Volume 163, Issue 6, 1 December 2010, Pages 1205–1211, https://doi.org/10.1111/j.1365-2133.2010.10009.x
Close
Search
Close
Search
Advanced Search
Search Menu
Summary
Background Usage of hair dye products containing p‐phenylenediamine (PPD) is a concern for PPD‐allergic individuals.
Objectives The present study investigates the role of dose and exposure time on elicitation of allergic contact dermatitis under conditions of permanent hair dyeing.
Methods Elicitation responses after application of a typical hair dye product containing 2% PPD for 30 min followed by rinsing were analysed in 38 PPD‐allergic individuals with a documented history of hair dye‐related allergy. Skin binding experiments in vitro were performed to distinguish the dose available for elicitation from the dose applied.
Results A positive reaction was elicited in 20 of 20 patients with grades ++ to +++ and 12 of 18 with grade + according to the classification of the International Contact Dermatitis Research Group. Under conditions of diagnostic patch testing (48 h exposure), the dose available for elicitation is more than 10‐fold higher compared with the dose available for hair dyeing (30‐min exposure, rinsing of product).
Conclusions This investigation demonstrates that under simulated hair dye use conditions the actual exposure to PPD is more than an order of magnitude lower than under diagnostic patch testing, although sufficient to elicit a clearly noticeable reaction in 84% of PPD patch test‐positive individuals.
allergic contact dermatitis, exposure‐dependent elicitation, measured exposure level, permanent hair dyeing, p‐phenylenediamine
© 2010 British Association of Dermatologists
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
Issue Section:
Original Articles > Contact dermatitis and allergy
You do not currently have access to this article.
Download all slides
Sign in
Get help with access
-
British Association of Dermatologists members
-
All other society members
Sign in through society site
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Sign in Register
Institutional access
- Sign in with a library card
- Sign in with username/password
- Recommend to your librarian
Sign in through your institution
Sign in through your institution
Institutional account management
Sign in as administrator
Get help with access
Institutional access
Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:
IP based access
Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.
Sign in through your institution
Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.
- Click Sign in through your institution.
- Select your institution from the list provided, which will take you to your institution's website to sign in.
- When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.
Sign in with a library card
Enter your library card number to sign in. If you cannot sign in, please contact your librarian.
Society Members
Society member access to a journal is achieved in one of the following ways:
Sign in through society site
Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:
- Click Sign in through society site.
- When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If you do not have a society account or have forgotten your username or password, please contact your society.
Sign in using a personal account
Some societies use Oxford Academic personal accounts to provide access to their members. See below.
Personal account
A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.
Some societies use Oxford Academic personal accounts to provide access to their members.
Viewing your signed in accounts
Click the account icon in the top right to:
- View your signed in personal account and access account management features.
- View the institutional accounts that are providing access.
Signed in but can't access content
Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.
Institutional account management
For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.
Purchase
Subscription prices and ordering for this journal
Purchasing options for books and journals across Oxford Academic
Short-term Access
To purchase short-term access, please sign in to your personal account above.
Don't already have a personal account? Register
Elicitation of the immune response to p‐phenylenediamine in allergic patients: the role of dose and exposure time - 24 Hours access
EUR €58.00
GBP £50.00
USD $62.00
Rental
This article is also available for rental through DeepDyve.
Advertisem*nt intended for healthcare professionals
Citations
Views
25
Altmetric
More metrics information
Email alerts
Article activity alert
Advance article alerts
New issue alert
Receive exclusive offers and updates from Oxford Academic
Citing articles via
Google Scholar
-
Latest
-
Most Read
-
Most Cited
Advertisem*nt intended for healthcare professionals
